What Causes Celiac Disease?

What Causes Celiac Disease?

Celiac disease is an autoimmune disease that develops as a result of a combination of genetic predisposition and environmental factors, in which the immune system overreacts to a protein called gluten. Gluten is a protein found in grains such as wheat, barley, rye and oats, and in celiac patients, the body develops an abnormal immune response to this protein. This reaction causes inflammation and damage in the small intestines, which makes it difficult to absorb nutrients. Genetic factors play an important role in the development of celiac disease; people who carry the HLA-DQ2 and HLA-DQ8 genes are more prone to celiac disease. However, genetic predisposition alone does not cause the development of the disease; environmental factors can also be effective. In particular, encountering gluten at an early age, stress, infections or other immune system triggers can contribute to the emergence of the disease. Celiac disease can sometimes remain hidden for years without showing symptoms, but it can manifest itself with various digestive, skin, nervous system and general health problems after gluten intake. For this reason, the disease can often last for a long time before being diagnosed.

Types of Celiac Disease

Celiac disease can manifest itself in different ways depending on the individual's age, immune system and severity of the disease.

Classic Celiac Disease: Classic celiac disease causes significant damage to the intestines and digestive problems. In such patients, digestive symptoms such as diarrhea, abdominal pain, and bloating are prominent. In addition, there is impaired absorption of nutrients.

Atypical Celiac Disease: Atypical celiac disease may not present with classic symptoms. There may be no damage to the intestines, but other symptoms of celiac disease may occur. These symptoms, in addition to limited digestive problems, can also be observed in other parts of the body such as headache, anemia, and joint pain.

Silent Celiac Disease: Silent celiac disease is a condition in which the patient does not experience any obvious symptoms, but the immune system reacts to gluten. In this case, damage may occur in the intestines, but symptoms may not appear. Such patients are usually diagnosed with routine screenings.

Latent Celiac Disease: Latent celiac disease is a condition in which individuals are predisposed to celiac disease but do not show any symptoms. These patients may develop celiac disease when they start consuming gluten.

How Is Celiac Disease Diagnosed?

The diagnosis of celiac disease is made by a combination of clinical symptoms and various tests. In Dr. Nurcivan Ünsal Üz's holistic medical approach, the diagnostic process is not limited to physical symptoms alone; it is considered as a whole, taking into account the emotional and psychological state. The most commonly used test for the diagnosis of celiac disease is the anti-transglutaminase (tTG) IgA blood test. This test measures the immune system's response to gluten proteins. High tTG levels may indicate celiac disease. To see if there is damage to the intestine, doctors may take a biopsy of the small intestine. The biopsy shows how much damage has been done to the villi in the intestinal wall. HLA-DQ2 and HLA-DQ8 genetic tests are more common in individuals who are predisposed to celiac disease. However, this test alone does not provide a diagnosis.

How Is Celiac Disease Treated?

The basis of celiac disease treatment is a lifelong gluten-free diet. This diet reduces inflammation in the intestines, aids healing, and prevents damage caused by gluten in the body. In Dr. Nurcivan Ünsal Üz's holistic medical approach, the treatment process does not only include a gluten diet, but also adopts an approach that strengthens all body systems that will support the immune system and intestinal health. The most important step in the treatment of celiac disease is to completely avoid foods containing gluten. These foods include grains such as wheat, barley, and rye, and bread, pastry, pasta, and similar products made from them should be excluded from the diet. Probiotics and prebiotics are recommended to improve intestinal health. In addition, supplements such as bone broth and L-glutamine can accelerate intestinal healing. Stress management and psychological support are also very important in coping with celiac disease. Dr. Ünsal Üz emphasizes that relaxation techniques such as meditation, yoga, and breathing exercises help balance the immune system.

Does Excessive Fat Accumulation in the Body Cause Celiac Disease?

Does excessive fat accumulation in the body cause celiac disease? Excessive fat accumulation in the body is usually associated with factors such as excessive calorie intake, a sedentary lifestyle or metabolic disorders. However, celiac disease is not directly linked to such fat accumulation. Celiac disease is an autoimmune disease that develops as a result of the abnormal response of the immune system to foods containing gluten, such as wheat, barley and rye. This disease causes inflammation and damage in the small intestine, preventing the absorption of nutrients. In most celiac patients, weight loss and weakness may occur due to the inadequate absorption of nutrients when gluten-containing foods are consumed. However, if left untreated, celiac disease can disrupt the body's general health and lead to metabolic problems, which can cause excessive weight gain in some individuals. However, there is no scientific link that excessive fat accumulation directly causes celiac disease. It is possible for celiac patients to live a healthy life with the right treatment and diet.

Things to Consider in Gluten Diets

The gluten diet is the main treatment method for individuals with celiac disease and gluten sensitivity, but there are some important points to consider when implementing this diet. First of all, it is necessary to choose gluten-free foods correctly. Gluten is not only found in grains such as wheat, rye and barley, but can also be found in processed food products derived from these grains. Therefore, it is extremely important to read the label; some processed foods may contain trace amounts of gluten residue, despite the statement "gluten-free". In addition, most gluten-free products may be processed and contain additives and high sugar content, which can lead to unhealthy weight gain and further deterioration of intestinal health. In this context, turning to natural, unprocessed and organic foods as much as possible both increases nutritional value and maintains the general balance of the body. Supporting intestinal health is also a critical step for people on a gluten-free diet. Strengthening the intestinal flora can be provided by supplements such as probiotics and prebiotics. These improve the digestive system, strengthen the immune system and make it easier for the body to cope with a gluten-free diet. It is also very important to manage stress during a gluten-free diet. Stress can weaken the immune system and increase the body's response to gluten. In Dr. Nurcivan Ünsal Üz's holistic medical approach, mental and emotional health are considered elements that directly affect physical health. Therefore, incorporating stress management, meditation and relaxation techniques into the daily routine along with a gluten-free diet can accelerate the healing process for patients and help them re-establish the balance in their bodies.

What Health Problems Does Celiac Disease Cause?

Celiac disease not only affects the digestive system, but can also damage other organs and systems in the body. In Dr. Nurcivan Ünsal Üz’s holistic medical approach, not only the physical symptoms of celiac disease but also its effects on the entire body are addressed. Celiac disease damages the villi in the intestines, which makes it difficult to absorb nutrients. Symptoms such as anemia, diarrhea, abdominal pain and bloating are common. Impaired absorption of nutrients in the intestines leads to calcium and vitamin D deficiencies. This can lead to weakened bones and the risk of osteoporosis. Celiac disease can also affect the nervous system. Symptoms such as headaches, nerve damage, depression and anxiety can be seen. Celiac disease can also weaken the immune system’s ability to fight other diseases. Autoimmune diseases can become more common in this case.

Does Celiac Disease Kill? Why Does It Happen?

Does celiac disease kill or cause death? Although celiac disease is not directly fatal, it can cause serious health complications and negatively affect quality of life if left untreated. Celiac disease is an autoimmune disease in which the immune system reacts abnormally to foods containing gluten, causing inflammation and damage to the small intestine. If left untreated, damage to the intestine prevents the absorption of nutrients, which leads to serious nutritional deficiencies in the long term. These deficiencies can cause serious health problems such as anemia, osteoporosis, weakened immune system, and organ damage. Celiac disease that is left untreated for a long time can increase the risk of developing more fatal diseases such as cancer in the small intestine. In addition, untreated celiac can lead to the progression of autoimmune diseases, liver problems, neurological problems (e.g. neuropathy), and digestive system problems. These conditions can cause more damage to the body and lead to fatal complications if left untreated. However, appropriate treatment of celiac disease allows the disease to be controlled with a gluten-free diet and improves quality of life. Therefore, early diagnosis and proper treatment are critical to prevent the fatal consequences that celiac disease can cause.

Frequently Asked Questions About Celiac Disease Causes

What Are the Causes of Celiac Disease?

Celiac disease develops due to a combination of genetic predisposition and environmental factors. Gluten is a protein found in grains such as wheat, rye, and barley, and the immune system recognizes this protein as a foreign substance. In individuals genetically predisposed to celiac disease, environmental factors trigger the onset of the disease. The causes of celiac disease are the combination of genetic predisposition and environmental factors.

How Important Is Genetic Predisposition in the Development of Celiac Disease?

Celiac disease is a genetic disorder, and people carrying the genetic markers HLA-DQ2 and HLA-DQ8 have a higher risk of developing the disease. The likelihood of the disease increases in individuals with a family history of celiac disease. However, genetic predisposition alone is not sufficient for the disease to develop; environmental factors also play a crucial role.

What Are the Environmental Factors That Cause Celiac Disease?

Certain environmental factors play an important role in the development of celiac disease. These include early consumption of gluten-containing foods, disturbances in the gut flora, especially intestinal infections, and the effect of stress on the immune system. Environmental factors trigger the disease in individuals with genetic predisposition.

How Is the Onset of Celiac Disease in Infancy Explained?

The onset of celiac disease in infancy is usually explained by genetic predisposition and the early introduction of gluten-containing foods. Babies’ immune systems may be more sensitive to gluten, causing the disease to appear at an early age. Additionally, exclusive breastfeeding for the first six months supports immune system development and may reduce the risk of the disease.

Is There a Relationship Between Celiac Disease and Stress?

Stress is a factor that can trigger celiac disease. Since the disease develops due to an overreaction of the immune system, stress can weaken the immune system and increase the risk of disease onset. Stress can also worsen inflammation in the intestines.

Are There Any Vaccines That Cause Celiac Disease?

So far, research has not found evidence that vaccines cause celiac disease. However, some infections may activate the immune system and play a role in the development of the disease. Vaccines strengthen the immune system and protect against diseases.

Does Gluten Consumption Always Trigger Celiac Disease?

While gluten triggers the immune system in individuals with celiac disease, consuming gluten does not always immediately cause symptoms. However, gluten intake damages the intestines and can lead to serious health problems in the long term.

When Should People with Celiac Disease Start a Diet?

Once diagnosed with celiac disease, patients must avoid gluten-containing foods for life. Diet is the fundamental treatment method for controlling the disease. Starting a gluten-free diet reduces intestinal inflammation and initiates the healing process.

Can Celiac Disease Start at an Older Age?

Celiac disease can begin at any age. Although it is most commonly diagnosed in childhood, it can also appear in adulthood or old age. The disease can be seen at any age due to genetic predisposition and environmental factors. Celiac disease starting at an older age often presents with milder symptoms and can be harder to diagnose.

Is Celiac Disease Associated with Other Autoimmune Diseases?

Celiac disease is an autoimmune disease caused by the immune system attacking its own tissues and is often seen alongside other autoimmune diseases in genetically predisposed individuals. Thyroid diseases, lupus, rheumatoid arthritis, and type 1 diabetes are commonly associated with celiac disease.